Steroid DXM Powder Dextromethorphan Hydrobromide / Romilar CAS 125-69-9

DXM Pharmaceutical Raw Materials Antitussive Drugs Dextromethorphan Hydrobromide Monohydrate Powder For Weight Loss

DXM Chemical Details:

DXM Name:Dextromethorphan Hydrobromide Monohydrate,DXM
CAS: 125-69-9
EINECS No: 204-750-1
Molecular Formula: C18H28BrNO2
Molecular weight: 370.3244
Flash point: 247.8°C
Melting point: 116-119°C
Chemical Properties:White powder
Usage:An antitussive drug. Orally active synthetic analog. Analgesic. levomethorpham are controlled substances (opiates).
Biological Activity: Non-competitive, low affinity NMDA receptor antagonist. Antitussive, anticonvulsive and neuroprotective agent.

Dextromethorphan Hydrobromide Description：

Dextromethorphan Hydrobromide is the hydrobromide salt form of dextromethorphan, a synthetic, addictive property. This agent crosses the blood-brain-barrier and activates sigma opioid receptors on the cough center in the central nervous system, thereby suppressing the cough reflex.

Dextromethorphan Hydrobromide (DXM or DM) is an antitussive (cough suppressant) drug of the morphinan class with sedative and dissociative properties. It is one of the active ingredients in many over-the-counter cold and cough medicines, including generic labels and store brands, Benylin DM, Mucinex DM, Robitussin, NyQuil, Dimetapp, Vicks, Coricidin, Delsym, TheraFlu, and others. Dextromethorphan has also found numerous other uses in medicine, ranging from pain relief (as either the primary analgesic, or an opioid potentiater) over psychological applications to the treatment of addiction. It is sold in syrup, tablet, spray, and lozenge forms. In its pure form, dextromethorphan occurs as a white powder.

Dextromethorphan Hydrobromide Application：

DXM is also used recreationally.When exceeding label-specified maximum dosages,dextromethorphan acts as a dissociative hallucinogen.Its mechanism of action is via multiple effects, including actions as a nonselective serotonin reuptake inhibitor and a sigma-1 receptor agonist.

The major metabolite of DXM, dextrorphan, also acts as an NMDA receptor antagonist.In high doses this produces effects similar to, yet distinct from, the dissociative states created by other dissociative anaesthetic such as and .As well, the metabolite 3-methoxymorphinan of dextrorphan (thus a second-level metabolite of DXM) produces local anesthetic effects in rats with potency above dextrorphan, but below that of DXM.

Dextromethorphan Hydrobromide Use：

1.For dry cough,including upper respiratory tract infection (such as cold,pharyngitis,bronchitis,cough).

2.Research reagents,widely used in molecular biology,pharmacology research.This is the central antitussive,can inhibit the medulla cough centrum antitussive effect and produce.The antitussive effect is equal to or slightly.The general treatment dose not inhibit respiration,long-term use of no addiction and tolerance.